CD24 is a two-chain glycosylphosphatidylinositol-anchored glycoprotein that is expressed at various stages of B-cell development, starting with the pro-B-cell compartment in the bone marrow and continuing through mature, surface Ig positive B-cells.
CD24 is also present in the majority of acute lymphoblastic leukemias in the B-lineage as well as B-cell CCLs and non-Hodgkin’s lymphomas. CD24 could play a part in the regulation of B-cell maturation and proliferation as well as the control of autoimmunity. You can visit www.bosterbio.com/anti-cd24-picoband-trade-antibody-a00373-2-boster.html to know more about CD24 antibodies-online.
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By homophilic binding or binding to CD62P, CD24 functions as adhesion or costimulatory molecule involved in T and B cell activation and differentiation.
It is expressed on mature granulocytes, and on many epithelial cells. CD24 was first discovered by mice in the form of a non-heat stable antigen and was utilized as a marker for differentiation of the hematopoietic cell and neuronal cells.
It is now known that CD24 is an inhibitory factor for T cells, which regulate their homeostasis as well as proliferation In B cells CD24 functions as a catalyst for cell differentiation and activation.
In hematopoietic cells, CD24 is recognized to bind molecules with dangerous-associated molecular patterns (DAMPs).
CD24 is a signal transducer and triggers the mitogen-activated protein kinase pathway that includes T- and B-cell development, apoptosis, cell binding, and granulocyte oxidative burst.